ML382, CAS [[1646499-97-9]]

Produktübersicht

• Artikelname: ML382, CAS [[1646499-97-9]]
• Artikelnummer: FBM-10-3937
• Hersteller Artikelnummer: 10-3937
• Alternativnummer: FBM-10-3937-10MG,FBM-10-3937-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: VU0485891, 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide

Produktbeschreibung

MRGPRX1 positive allosteric modulator

Produkteigenschaften

• Molekulargewicht: 360.43
• Reinheit: 99% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1646499-97-9]
• Formel: C18H20N2O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2