PF-06835919, CAS [[2102501-84-6]]

Produktübersicht

• Artikelname: PF-06835919, CAS [[2102501-84-6]]
• Artikelnummer: FBM-10-3958
• Hersteller Artikelnummer: 10-3958
• Alternativnummer: FBM-10-3958-1MG, FBM-10-3958-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[(1R,5S)-3-[2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]acetic acid

Produktbeschreibung

Ketohexokinase inhibitor

Produkteigenschaften

• Molekulargewicht: 356.35
• Reinheit: >98% by HPLC, NMR (conforms)
• Formulierung: White solid
• CAS Nummer: [2102501-84-6]
• Formel: C16H19F3N4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: PF-06835919 is a potent (IC50 = 10 nM KHK-C, 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade.1 It displayed high selectivity against other sugar kinases. PF-06835919 prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats.2 The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919.3 An interesting new tool to study metabolic and fatty liver diseases.