WX-02-23, CAS [[2929223-35-6]]

Produktübersicht

• Artikelname: WX-02-23, CAS [[2929223-35-6]]
• Artikelnummer: FBM-10-3969
• Hersteller Artikelnummer: 10-3969
• Alternativnummer: FBM-10-3969-5MG, FBM-10-3969-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-((1R,3S)-1-(benzo[d][1,3]dioxol-5-yl)-3-(morpholine-4-carbonyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)prop-2-en-1-one. Alternate Names: (1R,3S)-2-Acryloyl-1-(benzo[d][1,3]dioxol-5-yl)-N-morpholino-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

Produktbeschreibung

Spliceosome/FOXA1 modulator

Produkteigenschaften

• Molekulargewicht: 459.50
• Reinheit: >98% by HPLC, NMR (conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [2929223-35-6]
• Formel: C26H25N3O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: WX-02-23 is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 µM FOXA1, 12 µM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2