RMC-6236, CAS [[2765081-21-6]]

Produktübersicht

• Artikelname: RMC-6236, CAS [[2765081-21-6]]
• Artikelnummer: FBM-10-3976
• Hersteller Artikelnummer: 10-3976
• Alternativnummer: FBM-10-3976-1MG, FBM-10-3976-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (1S,2S)-N-[(7S,13S)-21-ethyl-20-[2-[(1S)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetrazapentacyclo[17.5.2.12,5.19,13.022,26]octacosa-1(25),2,5(28),19,22(26),23-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide. Alternate Names: Daraxonrasib

Produktbeschreibung

pan-RAS inhibitor

Produkteigenschaften

• Molekulargewicht: 811.06
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [2765081-21-6]
• Formel: C44H58N8O5S

Anwendungsbeschreibung

• Anwendungsbeschreibung: RMC-6236 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1,2 It binds with high affinity to cyclophilin A (KD = 55 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 131 nM for G12V, 364 nM for G12D and 154 nM for wild type). Active in in vivo xenograft models of NSCLC, PDAC, colorectal cancer, gastric carcinoma, and ovarian adenocarcinoma.2