YL-365

Produktübersicht

• Artikelname: YL-365
• Artikelnummer: FBM-10-3988
• Hersteller Artikelnummer: 10-3988
• Alternativnummer: FBM-10-3988-5MG, FBM-10-3988-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-(2-(4-(Benzyloxy)phenylacetamido)-1-(3-chloro-[1,1-biphenyl]-4-carbonyl)piperidine-4-carboxylic acid. Alternate Names: 1-[4-(3-Chlorophenyl)benzoyl]-4-[[2-(4-phenylmethoxyphenyl)acetyl]amino]piperidine-4-carboxylic acid

Produktbeschreibung

GPR34 antagonist

Produkteigenschaften

• Molekulargewicht: 583.08
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• Formel: C34H31ClN2O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and has been implicated in several types of cancer.2 YL-365 showed no activity against various other GPCRs as well as a panel of 378 kinases. It alleviated hyperalgesia in a mouse model of neuropathic pain via downregulation of iNOS in M1 microglia without any toxicity.