Chemical Name: 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide. Alternate Names: PF771
Selective Nav1.7 channel blocker
Molekulargewicht:
500.34
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[1235403-62-9]
Formel:
C18H12Cl2FN5O3S2
Anwendungsbeschreibung:
Potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3 It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 µM for resting channels.1 Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2
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