KY-226, CAS [[1621673-53-7]]

Produktübersicht

• Artikelname: KY-226, CAS [[1621673-53-7]]
• Artikelnummer: FBM-10-4004
• Hersteller Artikelnummer: 10-4004
• Alternativnummer: FBM-10-4004-5MG, FBM-10-4004-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide

Produktbeschreibung

PTP1B inhibitor

Produkteigenschaften

• Molekulargewicht: 481.67
• Reinheit: >98% TLC
• Formulierung: Off-white solid
• CAS Nummer: [1621673-53-7]
• Formel: C27H31NO3S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: KY-226 is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARgamma.1 It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2 It has been suggested that KY-226s anti-diabetic effects occur via enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2 KY-226 has also been shown to protect neurons from cerebral ischemia.3 This effect is mediated by restoration of tight junction proteins via activation of the Akt/FoxO1 pathway.4