SR0987, CAS [[303126-97-8]]

Produktübersicht

• Artikelname: SR0987, CAS [[303126-97-8]]
• Artikelnummer: FBM-10-4008
• Hersteller Artikelnummer: 10-4008
• Alternativnummer: FBM-10-4008-5MG, FBM-10-4008-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide

Produktbeschreibung

RORgammat agonist

Produkteigenschaften

• Molekulargewicht: 397.70
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [303126-97-8]
• Formel: C16H10F6NO2

Anwendungsbeschreibung

• Anwendungsbeschreibung: RORgammat is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORgammat agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORgammat agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.