URMC-099, CAS [[1229582-33-5]]

Produktübersicht

• Artikelname: URMC-099, CAS [[1229582-33-5]]
• Artikelnummer: FBM-10-4012
• Hersteller Artikelnummer: 10-4012
• Alternativnummer: FBM-10-4012-5MG, FBM-10-4012-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Produktbeschreibung

Mixed-lineage kinase 3 inhibitor

Produkteigenschaften

• Molekulargewicht: 421.54
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1229582-33-5]
• Formel: C27H27N5

Anwendungsbeschreibung

• Anwendungsbeschreibung: URMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid- degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5