PTC-209, CAS [[315704-66-6]]

Produktübersicht

• Artikelname: PTC-209, CAS [[315704-66-6]]
• Artikelnummer: FBM-10-4022
• Hersteller Artikelnummer: 10-4022
• Alternativnummer: FBM-10-4022-5MG, FBM-10-4022-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine

Produktbeschreibung

BMI-1 inhibitor

Produkteigenschaften

• Molekulargewicht: 495.19
• Reinheit: 98% by HPLC , NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [315704-66-6]
• Formel: C17H13Br2N5OS

Anwendungsbeschreibung

• Anwendungsbeschreibung: An inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8