GSK3326595, CAS [[1616392-22-3]]

Produktübersicht

• Artikelname: GSK3326595, CAS [[1616392-22-3]]
• Artikelnummer: FBM-10-4028
• Hersteller Artikelnummer: 10-4028
• Alternativnummer: FBM-10-4028-5MG, FBM-10-4028-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide. Alternate Names: EPZ015938

Produktbeschreibung

PRMT5 inhibitor

Produkteigenschaften

• Molekulargewicht: 452.56
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1616392-22-3]
• Formel: C24H32N6O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: GSK3326595 is a potent (IC50 = 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1 PRMT5 inhibition activated the p53 pathway via induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both in vitro and in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat. 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2 Currently in clinical Trials.3