iJMJD6, CAS [[899548-78-8]]

Produktübersicht

• Artikelname: iJMJD6, CAS [[899548-78-8]]
• Artikelnummer: FBM-10-4039
• Hersteller Artikelnummer: 10-4039
• Alternativnummer: FBM-10-4039-5MG, FBM-10-4039-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(3H-Imidazo[4,5-c]pyridine-2-yl)-6-methylchromen-2-one. Alternate Names: WL12

Produktbeschreibung

Arginine demethylase JMJD6 inhibitor

Produkteigenschaften

• Molekulargewicht: 277.28
• Reinheit: >98% HPLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [899548-78-8]
• Formel: C16H11N3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2