Chemical Name: (2S)-2-[[5-[Methyl-[(2-methyl-4-oxo-3H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid. Alternate Names: ICI D 1694, ZD1694
Thymidylate synthase inhibitor
Molekulargewicht:
458.49
Reinheit:
>98% by HPLC NMR (Conforms)
Formulierung:
Pale yellow solid
CAS Nummer:
[112887-68-0]
Formel:
C21H22N4O6S
Anwendungsbeschreibung:
Raltitrexed is an inhibitor of thymidylate synthase with significantly increased potency in many cancer cell lines when compared with 5-fluorouracil.1,2 It is also an inhibitor of the methyltransferase G9a (IC50 = 120 nM) and decreased Aß aggregates in C. elegans indicating therapeutic potential for the treatment of Alzheimers disease.3
10-4052
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