AZD5904, CAS [[618913-30-7]]

Produktübersicht

• Artikelname: AZD5904, CAS [[618913-30-7]]
• Artikelnummer: FBM-10-4058
• Hersteller Artikelnummer: 10-4058
• Alternativnummer: FBM-10-4058-5MG, FBM-10-4058-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one, 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one. Alternate Names: TX4

Produktbeschreibung

Myeloperoxidase inhibitor

Produkteigenschaften

• Molekulargewicht: 252.29
• Reinheit: >98% TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [618913-30-7]
• Formel: C10H12N4O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: A mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inactivate the enzyme.1 This prevents production of hypochlorous acid and concomitant oxidative stress. Importantly, neutrophil bactericidal activity was slowed but not stopped. AZD5904 did not inactivate thyroid peroxidase or lactoperoxidase. AZD5904 prevented the onset and reversed established high-fat diet induced microvascular insulin resistance.2 It also alleviated the relaxation defect in hypertrophic induced pluripotent cardiomyocytes via restoration of MYBPC3 phosphorylation, suggesting potential therapeutic value in treating hypertrophic cardiomyopathy.3