ML277, CAS [[1401242-74-7]]

Produktübersicht

• Artikelname: ML277, CAS [[1401242-74-7]]
• Artikelnummer: FBM-10-4074
• Hersteller Artikelnummer: 10-4074
• Alternativnummer: FBM-10-4074-5MG, FBM-10-4074-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)(sulfonyl]-2-piperidinecarboxamide. Alternate Names: (R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide

Produktbeschreibung

Potent Kv7.1 activator

Produkteigenschaften

• Molekulargewicht: 471.59
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1401242-74-7]
• Formel: C23H25N3O4S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: ML277 is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG).1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4