UNC7467, CAS [[2922283-43-8]]

Produktübersicht

• Artikelname: UNC7467, CAS [[2922283-43-8]]
• Artikelnummer: FBM-10-4080
• Hersteller Artikelnummer: 10-4080
• Alternativnummer: FBM-10-4080-5MG, FBM-10-4080-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-(4-Phenylphenyl)-2,1-benzoxazole-5-carboxylic acid. Alternate Names: 3-([1,1-Biphenyl]-4-yl)benzo[c]isoxazole-5-carboxylic acid

Produktbeschreibung

IP6K inhibitor

Produkteigenschaften

• Molekulargewicht: 315.33
• Reinheit: >98% TLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [2922283-43-8]
• Formel: C20H13NO3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent inhibitor of inositol hexakisphosphate kinase (IP6K) - the isoform IP3K1 regulates metabolism, promotes insulin secretion from ß cells, attenuates certain aspects of insulin signaling, and reduces whole-body energy expenditure by inhibiting adipocyte thermogenesis, thus making it an attractive target for treatment of obesity and obesity-induced metabolic dysfunction. It is selective for IP6K1 and 2 over IP6K3 (IC50s = 8.9 nM, 4.9 nM, and 1320 nM respectively). EC50 = 1.0 µM and 0.24 µM at 3hr and 18 hr respectively in intact HCT116 cells ([33]P-Pi efflux). Selective against a panel of 30 protein kinases and 5 CYP isoforms. UNC7467 improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake in diet-induced obese mice.