VY-3-135, CAS [[1824637-41-3]]

Produktübersicht

• Artikelname: VY-3-135, CAS [[1824637-41-3]]
• Artikelnummer: FBM-10-4096
• Hersteller Artikelnummer: 10-4096
• Alternativnummer: FBM-10-4096-5MG,FBM-10-4096-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 3-Ethyl-2-[hydroxy(diphenyl)methyl]-N-[(2R)-2-hydroxypropyl]benzimidazole-5-carboxamide

Produktbeschreibung

Acetyl-CoA synthetase 2 inhibitor

Produkteigenschaften

• Molekulargewicht: 429.52
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white to pale yellow solid
• CAS Nummer: [1824637-41-3]
• Formel: C26H27N3O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent (IC50 = 44 nM) and selective inhibitor of acetyl-CoA synthetase 2 (ACSS2), an enzyme that is upregulated in nutrient-stressed cancer cells.1 It completely blocked fatty acid synthesis from acetate in SKBR3 breast cancer cells. VY-3-135 caused growth inhibition of mouse and human triple negative breast cancer cells that expressed high levels of ACSS2 but not those that expressed low levels. It displayed no effects on gene regulation.

Bilder

10-4096