CPI-444, CAS [[1202402-40-1]]

Produktübersicht

• Artikelname: CPI-444, CAS [[1202402-40-1]]
• Artikelnummer: FBM-10-4101
• Hersteller Artikelnummer: 10-4101
• Alternativnummer: FBM-10-4101-5MG, FBM-10-4101-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-(5-methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine. Alternate Names: Ciforadenant

Produktbeschreibung

Adenosine A2A receptor antagonist

Produkteigenschaften

• Molekulargewicht: 407.43
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [1202402-40-1]
• Formel: C20H21N7O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA in HEK-293 cells with an IC50 = 17.03 nM. CPI-444 monotherapy or in combination with anti-PD-1, anti-PD-L1, and anti-CTLA-4 induced T-cell-mediated tumor responses, inhibited tumor growth, and enabled antitumor immune memory.1,2 Currently in clinical trials for multiple cancers.3