Galunisertib, CAS [[700874-72-2]]

Produktübersicht

• Artikelname: Galunisertib, CAS [[700874-72-2]]
• Artikelnummer: FBM-10-4110
• Hersteller Artikelnummer: 10-4110
• Alternativnummer: FBM-10-4110-5MG,FBM-10-4110-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: LY2157299

Produktbeschreibung

TGFß receptor 1 inhibitor / Cancer immunotherapeutic

Produkteigenschaften

• Molekulargewicht: 369.43
• Reinheit: 98%, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [700874-72-2]
• Formel: C22H19N5O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Galunisertib is a TGF-B kinase (ALK5) antagonist.1 It stimulated hematopoiesis from primary myelodysplastic syndrome bone marrow specimens via downregulation of SMAD2 phosphorylation.2 It has been in clinical trials for treatment of various cancers.3-5 Galunisertib has more recently been used to enhance the anti-neuroblastoma activity of anti-GD2 antibody Dinutuximab with natural killer cells6 and preserved the function of in vitro expanded natural killer cells in AML and colon cancer models7. Galunisertib reversed TGF and regulatory T cell mediated suppression of human T cell proliferation. In combination with PD-L1 blockade, it resulted in improved tumor growth inhibition and complete regressions in colon carcinoma models.8