I-BET762, CAS [[1260907-17-2]]

Produktübersicht

• Artikelname: I-BET762, CAS [[1260907-17-2]]
• Artikelnummer: FBM-10-4122
• Hersteller Artikelnummer: 10-4122
• Alternativnummer: FBM-10-4122-5MG, FBM-10-4122-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (4S)- 6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide. Alternate Names: GSK525762

Produktbeschreibung

BET bromodomain inhibitor / Supresses Myc transcription

Produkteigenschaften

• Molekulargewicht: 423.90
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Tan solid
• CAS Nummer: [1260907-17-2]
• Formel: C22H22ClN5O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: I-BET762 is a potent inhibitor of the BET family of bromodomains with no activity at bromodomains BAZ2B, SP140, ATAD2, CREBBO, and PCAF.1,2 IC50s for H4Ac peptide displacement: BRD2 = 32.5nM, BRD3 = 42.4nM, BRD4 = 36.1nM.1 It was able to suppress proinflammatory proteins by macrophage, block acute inflammation in mice1, and suppressed the inflammatory function of T cells3. Inhibition of BET bromodomains results in downregulation of Myc transcription, an important oncogene.4