Alisertib, CAS [[1028486-01-2]]

Produktübersicht

• Artikelname: Alisertib, CAS [[1028486-01-2]]
• Artikelnummer: FBM-10-4124
• Hersteller Artikelnummer: 10-4124
• Alternativnummer: FBM-10-4124-5MG, FBM-10-4124-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid. Alternate Names: MLN8237

Produktbeschreibung

Aurora A inhibitor, Destablizes Myc

Produkteigenschaften

• Molekulargewicht: 518.92
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1028486-01-2]
• Formel: C27H20ClFN4O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.