Cediranib, CAS [[288383-20-0]]

Produktübersicht

• Artikelname: Cediranib, CAS [[288383-20-0]]
• Artikelnummer: FBM-10-4142
• Hersteller Artikelnummer: 10-4142
• Alternativnummer: FBM-10-4142-5MG, FBM-10-4142-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline. Alternate Names: AZD2171

Produktbeschreibung

VEGFR inhibitor

Produkteigenschaften

• Molekulargewicht: 450.51
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [288383-20-0]
• Formel: C25H27FN4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Cediranib is a highly potent (IC50 = <1 nM) inhibitor of VEGFR-2.1 It also inhibits VEGFR-1, VEGFR-3, c-Kit, and PDGFRß (IC50s respectively: 5 nM, 3 nM, 2nM, and 5 nm). It displays broad-spectrum activity in various human tumor models. Cediranib normalized tumor vasculature decreasing permeability, increasing blood perfusion, and allowing better drug delivery in glioblastoma patients.2,3 It enhanced transcription of MHC-I leading to enhanced CD8+ T cell infiltration and improved efficacy of anti-PD-L1 therapy.4