S07-2010, CAS [[1223194-71-5]]

Produktübersicht

• Artikelname: S07-2010, CAS [[1223194-71-5]]
• Artikelnummer: FBM-10-4148
• Hersteller Artikelnummer: 10-4148
• Alternativnummer: FBM-10-4148-5MG, FBM-10-4148-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 7-(2-((6-Oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetyl)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Produktbeschreibung

pan-AKR1C inhibitor

Produkteigenschaften

• Molekulargewicht: 371.46
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1223194-71-5]
• Formel: C19H21N3O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: S07-2010 is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50s for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4 = 360 nM). Dysregulated AKR1C3 expression (and overexpression of all AKR1C isoforms in general) is related to resistance to radio- and chemotherapy in various tumor types and is associated with development of and poor prognosis in many cancers. S07-2010 displayed cytotoxicity to doxorubicin-resistant MCF-7 cells (IC50 = 127.5 µM) and cisplatin-resistant A549 cells (IC50 = 5.51 µM). Combination treatment of chemotherapeutic agents and S07-2010 showed synergistic effects in drug-resistant cell lines.