Chemical Name: N-[2-(3,4 Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide
Sigma-1 antagonist
Molekulargewicht:
437.04
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[138356-21-5]
Formel:
C13H20Cl2N22HBr
Anwendungsbeschreibung:
BD1047 is a potent and selective sigma-1 antagonist (IC50s: sigma1 = 0.93nM, sigma2 = 47nM). .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced by cocaine.2 BD1047 attenuated high fat diet-induced peripheral neuropathy in mice.3 BD1047 displayed antinociceptive effects in several rodent pain models.4-6 It also inhibits the beta-adrenoreceptor (IC50 = 145 nM).1
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