Imiquimod is a Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties.1 Enhances innate immune system leading to Th1-mediated antitumor immune response.2 Increases levels of IFNa, TNFa, and IL-12. Imiquimod has also been shown to act as an antagonist at adenosine A1 and A2A receptors augmenting its proinflammatory effects.3,4 Clinically useful for the treatment of basal cell carcinoma, actinic keratosis, and genital warts. Imiquimod also upregulates the expression of opioid growth factor receptor(OGFr).5,6 OGF is involved in regulation of inhibitory kinases in the cell cycle process.
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