WC522

Produktübersicht

• Artikelname: WC522
• Artikelnummer: FBM-10-4241
• Hersteller Artikelnummer: 10-4241
• Alternativnummer: FBM-10-4241-5MG,FBM-10-4241-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Dvl-cholesterol interaction inhibitor

Produkteigenschaften

• Molekulargewicht: 380.53
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Amber viscous oil
• Formel: C24H32N2O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: WC522 blocks the cholesterol-dishevelled interaction leading to inhibition of ß-catenin signaling. It specifically inhibits the Dvl2-PDZ-cholesterol interaction (IC50 = 40 nM) leading to suppression of both Wnt-independent and Wnt-stimulated ß-catenin signaling (IC50 = 150 nM). WC522 inhibits cell proliferation in APC-truncated colorectal carcinoma cells and colorectal carcinoma HCT15 xenografts in mice.