Y-320, CAS [[288250-47-5]]

Produktübersicht

• Artikelname: Y-320, CAS [[288250-47-5]]
• Artikelnummer: FBM-10-4276
• Hersteller Artikelnummer: 10-4276
• Alternativnummer: FBM-10-4276-5MG, FBM-10-4276-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-(4-Chlorophenyl)-N-[3-cyano-4-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide

Produktbeschreibung

IL-17 inhibitor

Produkteigenschaften

• Molekulargewicht: 505.02
• Reinheit: >98% by HPLC, NMR (Conforms)
• Formulierung: Pale pink solid
• CAS Nummer: [288250-47-5]
• Formel: C27H29ClN6O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Y-320 is an inhibitor of IL-17 production (IC50 = 20 - 60 nM in CD4 T cells).1 It significantly inhibited the development and progression of arthritis and joint destruction in collagen-induced arthritis models. Y-320 acted synergistically with other chemotherapeutic agents to overcome multidrug resistance.2 It also enhances premature termination codon (PTC) readthrough resulting in increased protein levels and protein synthesis.3 Y-320 also acts as a potent oral sialylation inhibitor (IC50 = 200 nM in PDAC cells).4 It suppressed alpha-2,3/2,6-sialylation inhibiting PDAC tumor growth and remodeling the tumor microenvironment. Y-320 acted synergistically with anti-PD-1 therapy to overcome immune checkpoint blockade resistance.