Disopyramide is a clinically useful sodium channel blocker used as an antiarrhythmic for treatment of ventricular tachycardia1 and hypertrophic cardiomyopathy2. It decreases the rate of diastolic depolarization, decreases the upstroke velocity and increases the action potential duration of normal cardiac cells. It decreases the disparity between infarcted and normal myocardium refractory periods. Disopyramide has no effect on alpha or beta-adrenergic receptors but does display significant anticholinergic effects.3
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