Chemical Name: 5-(2,6-Dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridine-2-amine. Alternate Names: NVP-BKM120, BKM-120
PI3-kinase inhibitor
Molekulargewicht:
410.39
Reinheit:
99% by HPLC, NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[944396-07-0]
Formel:
C18H21F3N6O2
Anwendungsbeschreibung:
Potent pan-Class I PI3-kinase inhibitor (IC50s: p110alpha = 52 nM, p110ß = 166 nM, p110delta = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1µM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
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