(R)-GNE-140, CAS [[2003234-63-5]]

Produktübersicht

• Artikelname: (R)-GNE-140, CAS [[2003234-63-5]]
• Artikelnummer: FBM-10-4355
• Hersteller Artikelnummer: 10-4355
• Alternativnummer: FBM-10-4355-5MG, FBM-10-4355-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2R)-5-(2-Chlorophenyl)sulfanyl-4-hydroxy-2-(4-morpholin-4-ylphenyl)-2-thiophen-3-yl-1,3-dihydropyridin-6-one

Produktbeschreibung

Lactate dehydrogenase inhibitor

Produkteigenschaften

• Molekulargewicht: 499.04
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Off-white to pale orange solid
• CAS Nummer: [2003234-63-5]
• Formel: C25H23ClN3O3S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: (R)-GNE-140 is a potent (IC50s: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient. GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2