LGK974, CAS [[1243244-14-5]]

Produktübersicht

• Artikelname: LGK974, CAS [[1243244-14-5]]
• Artikelnummer: FBM-10-4381
• Hersteller Artikelnummer: 10-4381
• Alternativnummer: FBM-10-4381-5MG, FBM-10-4381-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[5-Methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide. Alternate Names: WNT974

Produktbeschreibung

Porcupine inhibitor

Produkteigenschaften

• Molekulargewicht: 396.45
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1243244-14-5]
• Formel: C23H20N6O

Anwendungsbeschreibung

• Anwendungsbeschreibung: LGK974 is a potent and selective inhibitor of Porcupine (IC50 = 1 nM). Inhibits Wnt signaling (IC50 = 0.4 nM) in vitro and in vivo.1 It displays efficacy in several cancer models including glioblastoma2,6, squamous cell3, renal cell carcinoma4, and non-small cell lung5. LGK974 reprogrammed the immune suppressive tumor microenvironment in a mouse model of glioblastoma to increase antitumor immune responses.6 It also potentiated anti-PD1 therapy by increasing DC3-like dendritic cells and decreasing myeloid suppressor cells. LGK974 attenuated myocardial ischemia-reperfusion injury by reducing inflammatory responses.7