Ki8751, CAS [[228559-41-9]]

Produktübersicht

• Artikelname: Ki8751, CAS [[228559-41-9]]
• Artikelnummer: FBM-10-4388
• Hersteller Artikelnummer: 10-4388
• Alternativnummer: FBM-10-4388-5MG,FBM-10-4388-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

VEGFR2 inhibitor

Produkteigenschaften

• Molekulargewicht: 469.42
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [228559-41-9]
• Formel: C24H18F3N3O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Very potent (IC50 = 0.9 nM) inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2).1 It also inhibited PDGFRalpha (IC50 = 67 nM), c-Kit (IC50 = 40 nM), and FGFR2 (IC50 = 170 nM). Ki8751 completely suppressed HUVEC growth at 1 nM. Ki8751 completely inhibited tumor growth in LC-6 human tumor xenografts 5mg/kg. Ki8751 displayed anti-influenza A and B activity via disruption of virus entry in a PDGFRß/GM3-dependent manner.2