CCT251236, CAS [[1693731-40-6]]

Produktübersicht

• Artikelname: CCT251236, CAS [[1693731-40-6]]
• Artikelnummer: FBM-10-4410
• Hersteller Artikelnummer: 10-4410
• Alternativnummer: FBM-10-4410-5MG, FBM-10-4410-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide

Produktbeschreibung

HSF stress pathway inhibitor

Produkteigenschaften

• Molekulargewicht: 552.63
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white/beige solid
• CAS Nummer: [1693731-40-6]
• Formel: C32H32N4O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Inhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2