ARN25499

Produktübersicht

• Artikelname: ARN25499
• Artikelnummer: FBM-10-4412
• Hersteller Artikelnummer: 10-4412
• Alternativnummer: FBM-10-4412-5MG, FBM-10-4412-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(3,4-Dimethoxyphenyl)-4-phenyl-6-(piperidin-4-yl)pyrimidin-2-amine

Produktbeschreibung

Cdc42 GTPase interaction inhibitor

Produkteigenschaften

• Molekulargewicht: 390.49
• Reinheit: 99% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• Formel: C23H26N4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: ARN25499 is a novel Cdc42 GTPase interaction inhibitor. It inhibits the interaction between Cdc42 and its downstream effectors (i.e PAK) instead of the Cdc42-GEF interaction. ARN25499 displayed activity against four melanoma cancer cell lines (IC50s: SKM28 13.5 µM, SKMeI3 8.1 µM, WM3248 12.8 µM, A375 9.7 µM) and one colon cancer line (IC50 = 11.2 µM SW480). It also displayed good pharmacokinetics in mice. ARN25499 also showed in vivo efficacy in melanoma PDX tumors in NSG mice at 10mg/kg.