Moxidectin, CAS [[113507-06-5]]

Produktübersicht

• Artikelname: Moxidectin, CAS [[113507-06-5]]
• Artikelnummer: FBM-10-4436
• Hersteller Artikelnummer: 10-4436
• Alternativnummer: FBM-10-4436-20MG, FBM-10-4436-100MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (1R,4S,4E,5S,6R,6S,8R,10E,13R,14E,16E,20R,21R,24S)-21,24-dihydroxy-4-methoxyimino-5,11,13,22-tetramethyl-6-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2-oxane]-2-one

Produktbeschreibung

Anthelmintic/YAP-TAZ blocker

Produkteigenschaften

• Molekulargewicht: 639.83
• Reinheit: >98% by HPLC NMR (conforms)
• Formulierung: White solid
• CAS Nummer: [113507-06-5]
• Formel: C37H53NO8

Anwendungsbeschreibung

• Anwendungsbeschreibung: Moxidectin is a macrocyclic lactone anthelmintic drug used in veterinary medicine for the treatment of various parasitic diseases. In 2018, It was approved for use in the treatment of river-blindness in humans.1 Moxidectin is also being investigated as a possible treatment for scabies in humans.2 Moxidectin inhibited the proliferation of several glioblastoma multiforme (GBM) cell lines via induction of apoptosis.3 It inhibited the MEK-ERK pathway resulting in blocking of nuclear translocation and transcription of the YAP/TAZ-TEAD complex in GBM cells. It suppressed growth of GBM tumors by 90% in an intracranial tumor model.