SBI-553, CAS [[1849603-72-0]]

Produktübersicht

• Artikelname: SBI-553, CAS [[1849603-72-0]]
• Artikelnummer: FBM-10-4449
• Hersteller Artikelnummer: 10-4449
• Alternativnummer: FBM-10-4449-5MG,FBM-10-4449-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

ß-Arrestin-biased NTSR1 modulator

Produkteigenschaften

• Molekulargewicht: 450.56
• Reinheit: >98% by HPLC NMR (conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [1849603-72-0]
• Formel: C26H31FN4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: SBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1, EC50 = 340 nM)).1 It acts as a ß-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ß-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.