Roxadustat, CAS [[808118-40-3]]

Produktübersicht

• Artikelname: Roxadustat, CAS [[808118-40-3]]
• Artikelnummer: FBM-10-4468
• Hersteller Artikelnummer: 10-4468
• Alternativnummer: FBM-10-4468-5MG,FBM-10-4468-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: FG-4592

Produktbeschreibung

Prolyl hydroxylase domain inhibitor / HIF stabilizer

Produkteigenschaften

• Molekulargewicht: 352.35
• Reinheit: 99% by HPLC
• Formulierung: Off-white or white solid
• CAS Nummer: [808118-40-3]
• Formel: C19H16N2O5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Roxadustat (808118-40-3) is a pan-prolyl hydroxylase domain (PHD) inhibitor (IC50 for PHD2 = 591 nM)1 that stabilizes hypoxia-inducible factor (HIF) leading to erythropoiesis. Currently in clinical trials for treatment of anemia related to chronic kidney disease.2 Roxadustat accelerated cutaneous wound healing and shortened healing time via improvement in epidermal stem cell proliferation and motility3 and increasing angiogenesis4. It displayed radioprotective effects in haematopoietic systems via up-regulation of HIF-1.5 Roxadustat displayed protective effects against atherosclerosis via activation of adipose HIF-2.6