IACS-010759, CAS [[1570496-34-2]]

Produktübersicht

• Artikelname: IACS-010759, CAS [[1570496-34-2]]
• Artikelnummer: FBM-10-4475
• Hersteller Artikelnummer: 10-4475
• Alternativnummer: FBM-10-4475-5MG, FBM-10-4475-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-[5-Methyl-1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-1,2,4-triazol-3-yl]-3-[4-(trifluoromethoxyphenyl]-1,2,4-oxadiazole

Produktbeschreibung

Mitochondrial Complex I Inhibitor

Produkteigenschaften

• Molekulargewicht: 562.57
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White to off-white solid
• CAS Nummer: [1570496-34-2]
• Formel: C25H25F3N6O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: IACS-010759 (1570496-34-2) is a potent (IC50 = 1.1 nM isolated mouse complex I) and selective inhibitor of complex I of the mitochondrial electron transport chain (OXPHOS). IACS-010759 displayed in vivo efficacy in glycolysis-deficient glioblastoma and AML models without cytotoxicity to normal cells. The lack of cytotoxicity to normal cells, as opposed to other complex I inhibitors, is attributed to its unique binding location on complex I.2 Complex I inhibition by IACS-010759 causes an ROS-induced decrease in the endogenous PP2A inhibitor CIP2A leading to cell death.3 It has also displayed potential in various chemotherapy-resistant cancer cell lines.4-7