98% by TLC [1% methanol in methylene chloride Rf = 0.35], NMR (Conforms)
Formulierung:
Beige solid
CAS Nummer:
[405060-95-9]
Formel:
C21 H17 Cl3 N4 O S
Anwendungsbeschreibung:
Endoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2alpha).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2alpha resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
