7-Cl-O-Nec1, CAS [[852391-15-2]]

Produktübersicht

• Artikelname: 7-Cl-O-Nec1, CAS [[852391-15-2]]
• Artikelnummer: FBM-10-4544
• Hersteller Artikelnummer: 10-4544
• Alternativnummer: FBM-10-4544-5MG,FBM-10-4544-25MG,FBM-10-4544-10MM/1MLDMSO
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Nec-1s, Necrostatin1-S

Produktbeschreibung

Rip1 blocker

Produkteigenschaften

• Molekulargewicht: 277.71
• Reinheit: 98% by TLC (5% methanol / methylene chloride, Rf = 0.55), NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [852391-15-2]
• Formel: C13H12ClN3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5