Polyamine biosynthesis inhibitor / SAM decarboxylase inhibitor
Molekulargewicht:
257.13
Reinheit:
98% by HPLC, NMR (Confirms)
Formulierung:
White solid
CAS Nummer:
[31959-87-2]
Formel:
C5H12N8 2HCl
Anwendungsbeschreibung:
Mitoguazone is a potent and reversible inhibitor of S-adenosylmethionine decarboxylase (SAMD or AdoMetDC).1,2 SAMD is a component of the polyamine-biosynthetic pathway, thus inhibition may lead to changes in polyamine metabolism.3 Mitoguazone has also been shown to inhibit diamine oxidase and induce spermidine/spermine N-acetyltransferase.4,5 Mitoguazone has been looked at as a potential anti-cancer treatment because of its ability to inhibit polyamine synthesis.6
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