NHI-2, CAS [[1269802-97-2]]

Produktübersicht

• Artikelname: NHI-2, CAS [[1269802-97-2]]
• Artikelnummer: FBM-10-4555
• Hersteller Artikelnummer: 10-4555
• Alternativnummer: FBM-10-4555-10MG, FBM-10-4555-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: Methyl 1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylate

Produktbeschreibung

LDHA inhibitor

Produkteigenschaften

• Molekulargewicht: 335.28
• Reinheit: 98% by HPLC, NMR (Confirms)
• Formulierung: Off-white solid
• CAS Nummer: [1269802-97-2]
• Formel: C17H12F3NO3

Anwendungsbeschreibung

• Anwendungsbeschreibung: NHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50 in vitro = 14.7 µM (NADH), 10.5 µM (Pyruvate).1 NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 µM normoxic and 4.0 µM hypoxic, LPC006 cells IC50 = 17.8 µM normoxic and 1.1 µM hypoxic) with increased efficacy in a cancer cells hypoxic environment.2 LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.