MF-438, CAS [[921605-87-0]]

Produktübersicht

• Artikelname: MF-438, CAS [[921605-87-0]]
• Artikelnummer: FBM-10-4558
• Hersteller Artikelnummer: 10-4558
• Alternativnummer: FBM-10-4558-5MG, FBM-10-4558-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole

Produktbeschreibung

SCD1 inhibitor

Produkteigenschaften

• Molekulargewicht: 421.44
• Reinheit: 98% by HPLC, NMR (Confirms)
• Formulierung: Off-white solid
• CAS Nummer: [921605-87-0]
• Formel: C19H18F3N5OS

Anwendungsbeschreibung

• Anwendungsbeschreibung: MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.