TH588, CAS [[1609960-31-7]]

Produktübersicht

• Artikelname: TH588, CAS [[1609960-31-7]]
• Artikelnummer: FBM-10-4602
• Hersteller Artikelnummer: 10-4602
• Alternativnummer: FBM-10-4602-5MG, FBM-10-4602-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride

Produktbeschreibung

MTH1/NUDT1 inhibitor

Produkteigenschaften

• Molekulargewicht: 331.63
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1609960-31-7]
• Formel: C13H12Cl2N4HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that ''sanitizes oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3