SHP099, CAS [[1801747-42-1]]

Produktübersicht

• Artikelname: SHP099, CAS [[1801747-42-1]]
• Artikelnummer: FBM-10-4604
• Hersteller Artikelnummer: 10-4604
• Alternativnummer: FBM-10-4604-5MG, FBM-10-4604-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-(4-Amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine

Produktbeschreibung

SHP2 inhibitor

Produkteigenschaften

• Molekulargewicht: 352.27
• Reinheit: 98% by HPLC, NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1801747-42-1]
• Formel: C16H19Cl2N5

Anwendungsbeschreibung

• Anwendungsbeschreibung: SHP099 is a potent (IC50 = 71 nM) and selective allosteric inhibitor of SHP2. SHP2 is a non-receptor tyrosine phosphatase that regulates cell survival and proliferation through activating the RAS-ERK pathway. It also mediates programmed cell death 1 (PD-1) and T-lymphocyte attenuator (BTLA) immune checkpoint pathways. Treatment with SHP099, in combination with ceritinib, halts growth of ALK-inhibitor resistant non-small-cell lung cancer cells.3 Thus, reduction of SHP2 activity is a potential important cancer therapy target. It showed no activity against a panel of 21 other human phosphatases and 66 kinases.