3PO, CAS [[18550-98-6]]

Produktübersicht

• Artikelname: 3PO, CAS [[18550-98-6]]
• Artikelnummer: FBM-10-4609
• Hersteller Artikelnummer: 10-4609
• Alternativnummer: FBM-10-4609-10MG, FBM-10-4609-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2E)-3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one

Produktbeschreibung

6-Phosphofructo-2-kinase (PFKFB3) inhibitor

Produkteigenschaften

• Molekulargewicht: 210.23
• Reinheit: 99% by HPLC, NMR (Conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [18550-98-6]
• Formel: C13H10N2O

Anwendungsbeschreibung

• Anwendungsbeschreibung: 3PO is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3). PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50 = 1.4 - 24 µM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1 Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4 Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5 3PO has also been used to reduce pathological angiogenesis.6