SRT1720 HCl, CAS [[1001645-58-4]]

Produktübersicht

• Artikelname: SRT1720 HCl, CAS [[1001645-58-4]]
• Artikelnummer: FBM-10-4628
• Hersteller Artikelnummer: 10-4628
• Alternativnummer: FBM-10-4628-5MG,FBM-10-4628-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: SIRT 1933

Produktbeschreibung

SIRT1 activator

Produkteigenschaften

• Molekulargewicht: 506.02
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1001645-58-4]
• Formel: C25H23N7OSHCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: SIRT1 activator (EC1.5 = 0.16 µM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob/ob mice and Zucker fa/fa rats. SRT1720 enhanced endurance running and protected against diet-induced obesity and insulin resistance via enhancement of oxidative metabolism in skeletal muscle, liver, and brown adipose tissue.2 It induced mitochondrial biogenesis in oxidant-induced renal proximal tube cell injury.3 SRT1720 repressed circadian clock gene expression and decreased H3 K9/K14 acetylation in a time-specific manner.4 It attenuated angiotensin II-induced atherosclerosis by inhibiting the vascular inflammatory response.5