VU0134992, CAS [[755002-90-5]]

Produktübersicht

• Artikelname: VU0134992, CAS [[755002-90-5]]
• Artikelnummer: FBM-10-4651
• Hersteller Artikelnummer: 10-4651
• Alternativnummer: FBM-10-4651-5MG, FBM-10-4651-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(2-Bromo-4-propan-2-yl)phenoxy)-N-(2,2,6,6-tetramethlpiperidin-4-yl)acetamide

Produktbeschreibung

Kir4.1 blocker

Produkteigenschaften

• Molekulargewicht: 411.38
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Off-white/tan solid
• CAS Nummer: [755002-90-5]
• Formel: C20H31BrN2O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2