Vorasidenib, CAS [[1644545-52-7]]

Produktübersicht

• Artikelname: Vorasidenib, CAS [[1644545-52-7]]
• Artikelnummer: FBM-10-4659
• Hersteller Artikelnummer: 10-4659
• Alternativnummer: FBM-10-4659-5MG, FBM-10-4659-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-(6-Chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine. Alternate Names: AG-881

Produktbeschreibung

Isocitrate dehydrogenase (IDH) 1/2 inhibitor

Produkteigenschaften

• Molekulargewicht: 414.74
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1644545-52-7]
• Formel: C14H13ClF6N6

Anwendungsbeschreibung

• Anwendungsbeschreibung: Vorasidenib is a highly potent (IC50s = 7 nM IDH2-R140Q, 0.6 nM IDH1-R132H/WT, and 0.25 nM Neurosphere TS603 IDH1-R132H), selective, and brain-penetrant inhibitor of mutant isocitrate dehydrogenase 1 and 2 (IDH1/2).1 It led to >97% inhibition of 2-hydroxyglutarate production in mIDH1 glioma tissue. Vorasidenib significantly improved progression-free survival and delayed time to next intervention in a phase 3 glioma trial.2