PB28 dihydrochloride, CAS [[172907-03-8]]

Produktübersicht

• Artikelname: PB28 dihydrochloride, CAS [[172907-03-8]]
• Artikelnummer: FBM-10-4665
• Hersteller Artikelnummer: 10-4665
• Alternativnummer: FBM-10-4665-5MG,FBM-10-4665-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride

Produktbeschreibung

High affinity sigma 2 ligand / Anti-SARS-COV2

Produkteigenschaften

• Molekulargewicht: 443.50
• Reinheit: 99% by HPLC NMR (Conforms)
• Formulierung: White or off-white solid
• CAS Nummer: [172907-03-8]
• Formel: C24H38N2O2HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: PB28 is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) sigma 2 agonist. Selective for sigma 2 over sigma1 (approx 30-40x).1,2 PB28 inhibited cell growth in MCF7 and MCF7 ADR breast cancer cells and displayed strong synergism with doxorubicin.3 PB28 potently inhibited Kv2.1 currents in a sigma-independent manner.4 PB28 was recently found to have potent (IC50 = 280 nM) anti-SARS-CoV2 activity.5

Bilder

10-4665